The final proposed mechanism of RBC vasodilation inside the presence of nitrite is definitely the reduction of nitrite to NO by Hb. Brooks 1st examined the nitrite Hb conversation in 1937 which perform was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 1937;